Low Dose Immunotherapy, (LDI), is a revolutionary treatment that has been shown to provide dramatic relief of symptoms and improvement in health for patients with a wide range of chronic illnesses, including Lyme disease, chronic fatigue syndrome, fibromyalgia, Hashimoto’s, multiple sclerosis, Crohn’s disease, ulcerative colitis, interstitial cystitis and lupus. It is effective and originally used for chronic allergies, where the treatment is called Low Dose Allergen (LDA).credit
How does LDI and LDA work?
LDI works by helping the immune system restore proper balance by reducing inflammation caused by foreign invaders (LDI) or allergens (LDA). LDI brings the immune system more in balance, helping it to fight pathogens more effectively. LDA is a treatment for “turning off” an overactive immune system. This applies to allergies, autoimmune diseases or any process in which the immune system is activated. LDA is different from other conventional immune therapies because it uses much lower concentrations of allergens and may be used to treat not only inhalant allergies, but also allergies to foods, chemicals and certain autoimmune or overactive immune conditions.
With a number of infections, the body’s immune system is able to kill the majority of pathogens, but a small amount of pathogens are able to evade the immune system. The small amount of remaining pathogens continue to stimulate a maladaptive inflammatory response that leads to chronic illness, including chronic Lyme disease, chronic fatigue syndrome, fibromyalgia and a wide variety of autoimmune diseases.
We know that Lyme-related bacteria can be difficult to completely eliminate from the body due to the bacteria’s ability to mutate and hide within the body. But even if the bacteria are almost completely destroyed by antibiotic therapy, this may not turn off the immune response that is causing most of the symptoms. In this case, chronic Lyme is more like an autoimmune disease.
Most autoimmune diseases are triggered by an initial infection. As the immune system fights the infection, it may begin to confuse the body’s own proteins with proteins made by foreign invaders such as bacteria and viruses. Even after the bacteria have been eliminated, the immune system remains activated, and an autoimmune reaction triggered by the bacteria has been launched.
What is in a LDI/LDA dose and how is it administered?
LDI combines specific antigens (bacteria, toxins, or other foreign substances that induce an immune response in the body) with an enzyme called beta-glucuronidase. This enzyme attracts T cells, which are specialized white blood cells involved in the immune response and tells the T cells to pay attention to whatever antigens are included with the enzyme. Then the enzyme causes the down-regulation, or desensitization of TH2, the part of the immune system that was over-reacting to the included antigens. When the over-activated TH2 portion of the immune system is reduced, the depressed TH1 immunity is enhanced, which can effectively destroy intracellular infections.
LDI can be administered by intradermal injection or by sublingual dosing. We typically use sublingual dosing, making it the easiest option for our patients. Doses given sublingually are placed under the tongue and held for a short period of time, typically about 30 seconds. In sublingual dosing, the treatment is absorbed through the mucus membranes in the mouth.
What can be treated with LDI and LDA?
Low-dose immunotherapy has proven to be a safe and effective treatment for many chronic illnesses that previously had no effective treatment options, or which were often treated with expensive and toxic prescription medications. Some of the chronic illnesses that have seen improvement with LDI therapy include: